- 专利标题: BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS
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申请号: US17812061申请日: 2022-07-12
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公开(公告)号: US20230192884A1公开(公告)日: 2023-06-22
- 发明人: Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
- 申请人: AMGEN RESEARCH (MUNICH) GMBH
- 申请人地址: DE Munich
- 专利权人: AMGEN RESEARCH (MUNICH) GMBH
- 当前专利权人: AMGEN RESEARCH (MUNICH) GMBH
- 当前专利权人地址: DE Munich
- 分案原申请号: US15422647 2017.02.02
- 主分类号: C07K16/30
- IPC分类号: C07K16/30 ; C07K16/28 ; A61K39/395 ; C07K16/46
摘要:
The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3cε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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