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公开(公告)号：US11661462B2
公开(公告)日：2023-05-30
申请号：US15329672
申请日：2015-07-31
发明人： Benno Rattel , Matthias Friedrich , Peter Kufer , Patrick Hoffmann , Tobias Raum , Markus Münz , Ines Herrmann , Ralf Lutterbüse , Elisabeth Nahrwold
IPC分类号： C07K16/46 , C07K16/28 , C07K14/765 , A61K39/00
CPC分类号： C07K16/468 , C07K14/765 , C07K16/2803 , C07K16/2809 , A61K2039/505 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/94 , C07K2319/31
摘要： The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US10781264B2
公开(公告)日：2020-09-22
申请号：US15422661
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11434302B2
公开(公告)日：2022-09-06
申请号：US15422647
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , C07K16/46
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170349668A1
公开(公告)日：2017-12-07
申请号：US15329672
申请日：2015-07-31
发明人： Benno Rattel , Matthias Friedrich , Peter Kufer , Patrick Hoffmann , Tobias Raum , Markus Münz , Ines Herrmann , Ralf Lutterbüse , Elisabeth Nahrwold
IPC分类号： C07K16/46 , C07K16/28 , C07K14/765 , A61K39/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K14/765 , C07K16/2803 , C07K16/2809 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/94 , C07K2319/31
摘要： The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20230192884A1
公开(公告)日：2023-06-22
申请号：US17812061
申请日：2022-07-12
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , C07K16/46
CPC分类号： C07K16/30 , C07K16/2863 , C07K16/2803 , C07K16/3053 , C07K16/2875 , C07K16/2887 , A61K39/39558 , C07K16/28 , C07K16/2809 , C07K16/468 , C07K2317/33 , C07K2319/00 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/94
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3cε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20200048357A1
公开(公告)日：2020-02-13
申请号：US16373083
申请日：2019-04-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/28 , A61K39/395 , C12N5/16 , C12N15/63
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US10301391B2
公开(公告)日：2019-05-28
申请号：US15422619
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170218078A1
公开(公告)日：2017-08-03
申请号：US15422647
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
CPC分类号： C07K16/30 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/94 , C07K2319/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11352433B2
公开(公告)日：2022-06-07
申请号：US16373083
申请日：2019-04-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/28 , C12N5/10 , C12N5/12 , C12N15/63 , A61K39/395 , C12N5/16 , C07K14/715 , A61K39/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170218079A1
公开(公告)日：2017-08-03
申请号：US15422661
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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