Invention Publication
- Patent Title: SITU DETERMINATION OF ALUM FILLING EVENNESS AND SEDIMENTATION IN PHARMACEUTICAL PRODUCTS USING WATER PROTON NMR
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Application No.: US18170114Application Date: 2023-02-16
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Publication No.: US20230194447A1Publication Date: 2023-06-22
- Inventor: Yihua (Bruce) YU , Marc TARABAN , Christopher FOX
- Applicant: UNIVERSITY OF MARYLAND, BALTIMORE , ACCESS TO ADVANCED HEALTH INSTITUTE
- Applicant Address: US MD BALTIMORE
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,ACCESS TO ADVANCED HEALTH INSTITUTE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,ACCESS TO ADVANCED HEALTH INSTITUTE
- Current Assignee Address: US MD BALTIMORE
- The original application number of the division: US16593145 2019.10.04
- Main IPC: G01N24/08
- IPC: G01N24/08 ; G01N33/15
Abstract:
A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.
Public/Granted literature
- US12061160B2 In situ determination of acceptable resuspension in pharmaceutical products using water proton NMR Public/Granted day:2024-08-13
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