Invention Publication
- Patent Title: MUTANT REVERSE TRANSCRIPTASE WITH INCREASED THERMAL STABILITY AS WELL AS PRODUCTS, METHODS AND USES INVOLVING THE SAME
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Application No.: US18068739Application Date: 2022-12-20
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Publication No.: US20230203460A1Publication Date: 2023-06-29
- Inventor: Christian Helmut Bell , Harald Sobek , Heiko Walch , Kiyoshi Yasukawa , Misato Baba
- Applicant: Roche Diagnostics Operations, Inc.
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Priority: EP 000621.7 2017.04.11
- The original application number of the division: US16599407 2019.10.11
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/68 ; C12P19/34
Abstract:
The present invention relates to a mutant reverse transcriptase (RT) with increased thermal stability relative to the wildtype, a nucleic acid encoding the mutant RT, a cell comprising the mutant RT or the nucleic acid, a kit comprising the mutant RT, the use of the mutant RT for cDNA synthesis, method for reverse transcription of RNA comprising synthesizing cDNA with the use of the mutant RT and a method for detecting an RNA marker in a sample with the use of the mutant RT.
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