Polyphase power amplifiers for load insensitivity are disclosed. In certain embodiments, a polyphase transmit system includes an intermediate frequency transceiver including a first complex mixer that outputs a plurality of intermediate frequency transmit signals of different phases, and an intermediate frequency to radio frequency module including a second complex mixer that generates a plurality of radio frequency transmit signals of different phases based on the plurality of intermediate frequency transmit signals, and a polyphase power amplifier that receives the plurality of radio frequency transmit signals and outputs an amplified radio frequency signal. The polyphase transmit system further includes an antenna that transmits the amplified radio frequency signal.