发明公开
- 专利标题： METHODS FOR TARGETED INSERTION OF EXOGENOUS SEQUENCES IN CELLULAR GENOMES
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申请号： US17996733申请日： 2021-05-06
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公开(公告)号： US20230212613A1公开(公告)日： 2023-07-06
- 发明人: Ming YANG , Alexandre JUILLERAT , Philippe DUCHATEAU , Patrick HONG
- 申请人： CELLECTIS S.A.
- 申请人地址： FR Paris
- 专利权人： CELLECTIS S.A.
- 当前专利权人： CELLECTIS S.A.
- 当前专利权人地址： FR Paris
- 优先权： DK 202070366 2020.06.10
- 国际申请： PCT/EP2021/061999 2021.05.06
- 进入国家日期： 2022-10-20
- 主分类号： C12N15/90
- IPC分类号： C12N15/90 ; C07K14/725 ; C12N9/22 ; C12N5/0783
摘要：
The present disclosure provides methods for targeted insertion of an exogenous sequence at a genomic locus in a cell, wherein said insertion is induced by a sequence-specific endonuclease that has cleavage activity at said locus, at least 5 hours before the introduction into said cell of a DNA template comprising said exogenous sequence.
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