- 专利标题： CYCLIC CYANOENONE DERIVATIVES AS MODULATORS OF KEAP1
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申请号： US18015671申请日： 2021-07-15
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公开(公告)号： US20230257371A1公开(公告)日： 2023-08-17
- 发明人: Michael D. Altman , David A. Canditio , Alec H. Christian , Ornella Di Pietro , Min Lu , Umar Faruk Mansoor , Katrina Marie Mennie , Andrew J. Musacchio , Anandan Palani , Michael H. Reutershan , David Matthew Shaw , Ping Lui , Stephen St-Gallay
- 申请人： Michael ALTMAN , David A. CANDITO , Alec H. CHRISTIAN , Ornella DI PIETRO , Min LU , Umar Faruk MANSOOR , Katrina Marie MENNIE , Andrew J. MUSACCHIO , Anandan PALANI , Michael H. REUTERSHAN , David Matthew SHAW , MERCK SHARP & DOHME LLC , MSD R&D INNOVATION CENTRE LIMITED
- 申请人地址： US MA Boston
- 专利权人： Merck Sharp & Dohme LLC
- 当前专利权人： Merck Sharp & Dohme LLC
- 当前专利权人地址： US NJ Rahway
- 优先权： EP 186249.7 2020.07.16
- 国际申请： PCT/EP2021/069897 2021.07.15
- 进入国家日期： 2023-01-11
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D403/06 ; C07D265/36 ; C07D401/06 ; C07D491/048 ; C07D471/04 ; C07D209/96 ; C07D487/04 ; C07D307/94
摘要：
The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.
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