公开(公告)号：US20230257371A1

公开(公告)日：2023-08-17

申请号：US18015671

申请日：2021-07-15

申请人： Michael ALTMAN ,  David A. CANDITO ,  Alec H. CHRISTIAN ,  Ornella DI PIETRO ,  Min LU ,  Umar Faruk MANSOOR ,  Katrina Marie MENNIE ,  Andrew J. MUSACCHIO ,  Anandan PALANI ,  Michael H. REUTERSHAN ,  David Matthew SHAW ,  MERCK SHARP & DOHME LLC ,  MSD R&D INNOVATION CENTRE LIMITED

发明人： Michael D. Altman ,  David A. Canditio ,  Alec H. Christian ,  Ornella Di Pietro ,  Min Lu ,  Umar Faruk Mansoor ,  Katrina Marie Mennie ,  Andrew J. Musacchio ,  Anandan Palani ,  Michael H. Reutershan ,  David Matthew Shaw ,  Ping Lui ,  Stephen St-Gallay

IPC分类号： C07D413/04 ,  C07D403/06 ,  C07D265/36 ,  C07D401/06 ,  C07D491/048 ,  C07D471/04 ,  C07D209/96 ,  C07D487/04 ,  C07D307/94

CPC分类号： C07D413/04 ,  C07D403/06 ,  C07D265/36 ,  C07D401/06 ,  C07D491/048 ,  C07D471/04 ,  C07D209/96 ,  C07D487/04 ,  C07D307/94

摘要： The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.