- 专利标题： COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS
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申请号： US18062873申请日： 2022-12-07
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公开(公告)号： US20230277590A1公开(公告)日： 2023-09-07
- 发明人: Carl Alexander Kamb , Dora Toledo Warshaviak , Talar Tokatlian , Agnes Hamburger
- 申请人： A2 Biotherapeutics, Inc.
- 申请人地址： US CA Agoura Hills
- 专利权人： A2 Biotherapeutics, Inc.
- 当前专利权人： A2 Biotherapeutics, Inc.
- 当前专利权人地址： US CA Agoura Hills
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61P35/00 ; C07K14/725 ; C12N15/113
摘要：
The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
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