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公开(公告)号：US20240180969A1
公开(公告)日：2024-06-06
申请号：US18553326
申请日：2022-04-01
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K16/28 , C12N5/0783 , C12N15/66 , G01N33/574
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464411 , A61P35/00 , C07K16/2833 , C12N5/0636 , C12N15/66 , G01N33/57492 , A61K2239/13 , A61K2239/17 , A61K2239/21 , A61K2239/22 , G01N2474/20
摘要： The disclosure relates to antigen binding domains that specifically bind to a major histocompatibility class I (MHC I) complex comprising an a chain encoded by HLA-A*11 alleles. The disclosure further relates to antibodies and receptors comprising said antigen binding domains, and their use in diagnostics and adoptive cell therapy.
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公开(公告)号：US11602543B2
公开(公告)日：2023-03-14
申请号：US17662766
申请日：2022-05-10
IPC分类号： A61K35/17 , C07K14/725 , C12N15/113 , A61P35/00 , A61K38/00
摘要： The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
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公开(公告)号：US11730764B2
公开(公告)日：2023-08-22
申请号：US17809409
申请日：2022-06-28
发明人： Yuta Ando , Julyun Oh , Han Xu , Carl Alexander Kamb
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28 , C07K16/30 , A61K39/00
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2809 , C07K16/2833 , C07K16/2863 , C07K16/30 , A61K2039/507 , C07K2317/622 , C07K2319/03
摘要： The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.
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公开(公告)号：US20230029341A1
公开(公告)日：2023-01-26
申请号：US17757056
申请日：2020-12-11
IPC分类号： C07K14/705 , C07K14/725 , C07K16/28 , A61P35/00
摘要： Provided are polynucleotides comprising nucleic acid sequences encoding chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are vectors and immune cells comprising said polynucleotides.
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公开(公告)号：US20220389075A1
公开(公告)日：2022-12-08
申请号：US17755750
申请日：2020-11-10
发明人： Julyun OH , Chang Yi , Dora Toledo Warshaviak , Jee Young Mock , Mark Daris , Agnes Hamburger , James Johnston , Carl Alexander Kamb
IPC分类号： C07K14/725 , C07K14/705 , C12N9/12 , C12N5/0783 , C12N15/85 , A61K35/17 , C07K14/73
摘要： Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.
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公开(公告)号：US20220339194A1
公开(公告)日：2022-10-27
申请号：US17809409
申请日：2022-06-28
发明人： Yuta Ando , Agnes Hamburger , Jee Young Mock , Julyun OH , Han Xu , Carl Alexander Kamb
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28 , C07K16/30
摘要： The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.
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公开(公告)号：US11433100B2
公开(公告)日：2022-09-06
申请号：US17517559
申请日：2021-11-02
IPC分类号： A61K35/17 , C07K14/705 , A61P35/00 , C07K14/725
摘要： The disclosure provides immune cells comprising a first activator receptor specific to CEA, and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
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公开(公告)号：US12037377B2
公开(公告)日：2024-07-16
申请号：US17663148
申请日：2022-05-12
IPC分类号： C07K14/705 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K14/70503 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C07K16/2833 , C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/03
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
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公开(公告)号：US20240000938A1
公开(公告)日：2024-01-04
申请号：US18253721
申请日：2021-11-23
发明人： Carl Alexander Kamb , Agnes Hamburger , Breanna Diandreth , Han Xu , Julyun Oh
IPC分类号： A61K39/00 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/32 , C07K16/30 , A61K45/06 , A61P35/00 , C12N15/86 , C12N15/11 , C12N9/22
CPC分类号： A61K39/4632 , C07K14/70503 , C07K14/7051 , C07K16/2863 , C07K16/32 , C07K16/3007 , C07K16/2803 , A61K45/06 , A61K39/4611 , A61K39/4612 , A61K39/4613 , A61K39/464482 , A61K39/464468 , A61K39/464404 , A61P35/00 , C12N15/86 , C12N15/111 , C12N9/22 , C07K2319/03 , A61K2239/21 , A61K2239/22 , A61K2239/13 , C12N2310/20 , C12N2740/15043
摘要： The disclosure relates to immune cells comprising systems of two engineered receptors each having a ligand binding domain, collectively designed to target cells identified by loss of heterozygosity and used to treat a disease or disorder, for example, cancer. The disclosure provides immune cells expressing two engineered receptors, methods of making same, and polynucleotides and vectors encoding same.
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公开(公告)号：US20230277590A1
公开(公告)日：2023-09-07
申请号：US18062873
申请日：2022-12-07
IPC分类号： A61K35/17 , A61P35/00 , C07K14/725 , C12N15/113
CPC分类号： A61K35/17 , A61P35/00 , C07K14/7051 , C12N15/1138 , A61K38/00
摘要： The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
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