- 专利标题： GRP78-BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES
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申请号： US17837943申请日： 2022-06-10
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公开(公告)号： US20230028927A1公开(公告)日： 2023-01-26
- 发明人: Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R.M. Bradbury
- 申请人： Rutgers, The State University of New Jersey
- 申请人地址： US NJ New Brunswick
- 专利权人： Rutgers, The State University of New Jersey
- 当前专利权人： Rutgers, The State University of New Jersey
- 当前专利权人地址： US NJ New Brunswick
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K47/68 ; A61K39/395 ; C07K16/18 ; G01N33/574 ; A61P35/00 ; C07K16/28 ; C12N15/10 ; A61K38/07
摘要：
Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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