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公开(公告)号：US20240050580A1
公开(公告)日：2024-02-15
申请号：US18268125
申请日：2021-12-20
发明人： Renata Pasqualini , Wadih Arap , Fernanda I. Staquicini , Amin Hajitou , Wouter Driessen , Daniela Staquicini , Bettina Proneth
IPC分类号： A61K47/64 , C07K7/06 , A61K49/00 , A61K47/69 , A61K48/00 , A61K38/19 , A61K45/06 , A61P35/00 , A61K51/08
CPC分类号： A61K47/64 , C07K7/06 , A61K49/0002 , A61K47/6901 , A61K48/0041 , A61K38/191 , A61K45/06 , A61P35/00 , A61K51/08
摘要： In one aspect, the present disclosure relates to tumor associated macrophage (TAM) targeting peptide. In another aspect, the present disclosure relates to a method of targeting a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle. In yet another aspect, the present disclosure relates to a method of treating a tumor infiltrated with a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle.
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公开(公告)号：US11254751B2
公开(公告)日：2022-02-22
申请号：US16333898
申请日：2017-09-21
发明人： Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R. M. Bradbury
IPC分类号： C07K16/28 , A61K39/395 , C07K16/30 , A61P35/00 , G01N33/574 , C07K16/18 , A61K47/68 , A61K38/07 , C12N15/10 , A61K39/00
摘要： Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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公开(公告)号：US12103966B2
公开(公告)日：2024-10-01
申请号：US17837888
申请日：2022-06-10
发明人： Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R. M. Bradbury
IPC分类号： C07K16/18 , A61K39/395 , A61K47/68 , A61P35/00 , C07K16/30 , G01N33/574 , A61K38/07 , A61K39/00 , A61K49/00 , C07K14/47 , C07K16/00 , C07K16/28 , C12N15/10 , C12N15/64 , C12Q1/6869 , G01N33/50
CPC分类号： C07K16/18 , A61K39/3955 , A61K39/39558 , A61K47/6803 , A61K47/68031 , A61K47/68033 , A61P35/00 , C07K16/30 , C07K16/3023 , G01N33/574 , A61K38/07 , A61K2039/505 , A61K47/6817 , A61K47/6843 , A61K47/6849 , A61K47/6891 , A61K49/0008 , C07K14/47 , C07K16/005 , C07K16/28 , C07K16/2866 , C07K2317/21 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C12N15/1037 , C12N15/64 , C12N2810/00 , C12Q1/6869 , G01N33/5011 , G01N33/57423
摘要： Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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公开(公告)号：US20230293710A1
公开(公告)日：2023-09-21
申请号：US18052479
申请日：2022-11-03
IPC分类号： A61K47/68
CPC分类号： A61K47/6811 , A61K47/6889 , C07K16/28
摘要： The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
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公开(公告)号：US20220306763A1
公开(公告)日：2022-09-29
申请号：US17592828
申请日：2022-02-04
发明人： Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R.M. Bradbury
IPC分类号： C07K16/30 , C07K16/18 , A61K47/68 , A61P35/00 , A61K39/395 , C07K16/28 , A61K38/07 , C12N15/10 , G01N33/574
摘要： Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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公开(公告)号：US20230241203A1
公开(公告)日：2023-08-03
申请号：US18004517
申请日：2021-07-03
发明人： Renata Pasqualini , Wadih Arap , Steven Libutti , Christopher Markosian , Daniela Staquicini , Fenny Tang , Tracey Smith , Virginia Yao
IPC分类号： A61K39/215 , A61K45/06 , A61P31/14 , C12N15/86
CPC分类号： A61K39/215 , A61K45/06 , A61P31/14 , C12N15/86 , A61K2039/5256
摘要： The present disclosure includes an immunogenic composition comprising an effective amount of a therapeutic engineered phage and a pharmaceutically acceptable carrier. In certain aspects, the disclosure includes a method of stimulating an immune response in a subject comprising administering to the subject a composition comprising an effective amount of a therapeutic engineered phage. In certain aspects, the disclosure includes a method for treating, ameliorating, and/or preventing a coronavirus infection in a subject comprising administering a composition comprising an effective amount of a therapeutic engineered phage.
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公开(公告)号：US20230139913A1
公开(公告)日：2023-05-04
申请号：US18047533
申请日：2022-10-18
发明人： Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R.M. Bradbury
IPC分类号： C07K16/30 , C07K16/18 , A61K47/68 , A61P35/00 , A61K39/395 , C07K16/28 , A61K38/07 , C12N15/10 , G01N33/574
摘要： Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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公开(公告)号：US20220332759A1
公开(公告)日：2022-10-20
申请号：US17765379
申请日：2020-10-01
摘要： The present disclosure relates, in one aspect, to the identification of certain peptides that allow for transport of a solid particle across the air-blood barrier in the lungs. In certain embodiments, the solid particle comprises any sort of solid cargo to which the peptides contemplated in the disclosure can be attached.
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公开(公告)号：US12060415B2
公开(公告)日：2024-08-13
申请号：US17592828
申请日：2022-02-04
发明人： Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R. M. Bradbury
IPC分类号： C07K16/18 , A61K39/395 , A61P35/00 , C07K16/30 , G01N33/574 , A61K38/07 , A61K39/00 , A61K47/68 , A61K49/00 , C07K14/47 , C07K16/00 , C07K16/28 , C12N15/10 , C12N15/64 , C12Q1/6869 , G01N33/50
CPC分类号： C07K16/18 , A61K39/3955 , A61K39/39558 , A61P35/00 , C07K16/30 , C07K16/3023 , G01N33/574 , A61K38/07 , A61K2039/505 , A61K47/6803 , A61K47/6817 , A61K47/6843 , A61K47/6849 , A61K47/6891 , A61K49/0008 , C07K14/47 , C07K16/005 , C07K16/28 , C07K16/2866 , C07K2317/21 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C12N15/1037 , C12N15/64 , C12N2810/00 , C12Q1/6869 , G01N33/5011 , G01N33/57423
摘要： Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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公开(公告)号：US20240115722A1
公开(公告)日：2024-04-11
申请号：US18360287
申请日：2023-07-27
IPC分类号： A61K47/68
CPC分类号： A61K47/6811 , A61K47/6889 , C07K16/28
摘要： The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
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