Methods, systems and devices for interference cancellation of high-power input signals in the analog domain are described. An example method of interference cancellation includes receiving, via an antenna, an analog signal comprising a signal of interest and one or more interfering signals, wherein the one or more interfering signals comprises a high-power interfering signal with a signal power greater than 15 dBm, determining, based on a reference signal corresponding to the high-power interfering signal, an update to at least one parameter of the reference signal, wherein the update is determined by minimizing a cost function of a difference between the reference signal and the high-power interfering signal, generating, based on the update to the at least one parameter, a modified reference signal, and generating, based on coupling the modified reference signal to the analog signal, an interference-canceled signal comprising the signal of interest.