- 专利标题： MULTISPECIFIC ANTIBODIES THAT BIND BOTH MAIT AND TUMOR CELLS
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申请号： US17791549申请日： 2021-01-08
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公开(公告)号： US20230322952A1公开(公告)日： 2023-10-12
- 发明人: OLIVIER LANTZ , SEBASTIAN AMIGORENA , MICHAEL SAITAKIS , MAUDE GUILLOT-DELOST , EUGENE ZHUKOVSKY , PIERRE-EMMANUEL GERARD , MUSTAPHA FAROUDI
- 申请人： BIOMUNEX PHARMACEUTICALS , INSTITUT CURIE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
- 申请人地址： FR PARIS
- 专利权人： BIOMUNEX PHARMACEUTICALS,INSTITUT CURIE,INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
- 当前专利权人： BIOMUNEX PHARMACEUTICALS,INSTITUT CURIE,INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
- 当前专利权人地址： FR PARIS
- 优先权： EP 305011.7 2020.01.09 EP 305012.5 2020.01.09
- 国际申请： PCT/EP2021/050253 2021.01.08
- 进入国家日期： 2022-07-08
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; A61P35/00
摘要：
The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a Vα7.2 T cell receptor (TCR) and at least one domain that specifically binds a tumor associated antigen (TAA).
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