- 专利标题： PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES
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申请号： US18023589申请日： 2021-08-17
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公开(公告)号： US20230323469A1公开(公告)日： 2023-10-12
- 发明人: Ralf Dieter Hoffmann , Monique Stoffels
- 申请人： KONINKLIJKE PHILIPS N.V.
- 申请人地址： NL EINDHOVEN
- 专利权人： KONINKLIJKE PHILIPS N.V.
- 当前专利权人： KONINKLIJKE PHILIPS N.V.
- 当前专利权人地址： NL EINDHOVEN
- 优先权： EP 193628.3 2020.08.31
- 国际申请： PCT/EP2021/072774 2021.08.17
- 进入国家日期： 2023-02-27
- 主分类号： C12Q1/6886
- IPC分类号： C12Q1/6886 ; G16H20/10
摘要：
The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of two or more PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the 5 prediction of the radiotherapy response based on the gen expression profiles for the two or more PDE4D7 correlated genes.
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