- 专利标题: ENGINEERING GAMMA DELTA T CELLS WITH INTERLEUKIN-36 FOR IMMUNOTHERAPY
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申请号: US18014627申请日: 2021-07-09
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公开(公告)号: US20230338422A1公开(公告)日: 2023-10-26
- 发明人: Qingling Jiang , Yafeng Zhang , Shu Wu , Chunjing Wu
- 申请人: Nanjing Legend Biotech Co., Ltd.
- 申请人地址: CN Nanjing
- 专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人地址: CN Nanjing
- 优先权: WO TCN2020101069 2020.07.09
- 国际申请: PCT/CN2021/105424 2021.07.09
- 进入国家日期: 2023-01-05
- 主分类号: C07K14/54
- IPC分类号: C07K14/54 ; A61P35/00 ; A61K35/17 ; C12N15/63
摘要:
The present disclosure relates to a novel platform for immunotherapy which combines CAR or TCR engineered γδ T cells with armoring interleukin IL-36 that can be expressed constitutively or inducibly, or with a chimeric cytokine receptor comprising the endodomain of the IL-36 receptor. The system/platform and the associated methods according to the present disclosure have advantages such as increased immune cell potency and persistence for therapeutic applications.
公开/授权文献
- US1687602A Sign and means for mounting the same 公开/授权日:1928-10-16
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