ENGINEERING GAMMA DELTA T CELLS WITH INTERLEUKIN-36 FOR IMMUNOTHERAPY
摘要:
The present disclosure relates to a novel platform for immunotherapy which combines CAR or TCR engineered γδ T cells with armoring interleukin IL-36 that can be expressed constitutively or inducibly, or with a chimeric cytokine receptor comprising the endodomain of the IL-36 receptor. The system/platform and the associated methods according to the present disclosure have advantages such as increased immune cell potency and persistence for therapeutic applications.
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