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公开(公告)号：US11905327B2
公开(公告)日：2024-02-20
申请号：US16958397
申请日：2018-12-28
发明人： Wang Zhang , Shu Wu , Shuai Yang , Qi Pan , Chuan-Chu Chou
IPC分类号： C07K16/02 , A61K39/395 , A61P35/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US11505601B2
公开(公告)日：2022-11-22
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng Zhang , Shu Wu , Fei Sun , Shuai Yang , Chuan-Chu Chou
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US20220249563A1
公开(公告)日：2022-08-11
申请号：US17618642
申请日：2020-07-17
发明人： Tao Zhao , Yuanyuan Peng , An Tang , Sujuan Wang , Shuai Yang , Wang Zhang , Shu Wu , Ruidong Hao
IPC分类号： A61K35/17 , C07K16/18 , C07K14/725 , C07K14/705 , C07K14/71 , A61P35/00 , C12N5/0783
摘要： Provided herein are anti-DLL3 chimeric antigen receptors (CARs), DLL3 binding proteins and uses of such CARs or DLL3 binding proteins in the treatment of DLL3 associated disorders, such as small cell lung cancer.
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公开(公告)号：US20230338422A1
公开(公告)日：2023-10-26
申请号：US18014627
申请日：2021-07-09
发明人： Qingling Jiang , Yafeng Zhang , Shu Wu , Chunjing Wu
摘要： The present disclosure relates to a novel platform for immunotherapy which combines CAR or TCR engineered γδ T cells with armoring interleukin IL-36 that can be expressed constitutively or inducibly, or with a chimeric cytokine receptor comprising the endodomain of the IL-36 receptor. The system/platform and the associated methods according to the present disclosure have advantages such as increased immune cell potency and persistence for therapeutic applications.
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公开(公告)号：US20230144237A1
公开(公告)日：2023-05-11
申请号：US17605290
申请日：2020-04-22
发明人： Zhongyuan Tu , Hezhong Zhang , Yafeng Zhang , Shu Wu
IPC分类号： C07K14/725 , C12N5/0783 , C12N15/86 , C07K16/30 , C07K16/28 , A61K35/17
CPC分类号： C07K14/7051 , C12N5/0636 , C12N15/86 , C07K16/30 , C07K16/2866 , C07K16/28 , A61K35/17 , C12N2740/15043 , C12N2501/2302 , C07K2319/00
摘要： The present disclosure provides systems for inducing activity of immune cells and methods of immunotherapy. Systems of the present disclosure for inducing immune cell activity comprise a chimeric antigen receptor, a T cell receptor, and various combinations thereof.
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公开(公告)号：US20230136252A1
公开(公告)日：2023-05-04
申请号：US17910608
申请日：2021-03-12
发明人： Wang Zhang , Jintao Guo , Fengyuan TANG , Shuai Yang , Yuanyuan Peng , An Tang , Xiaojie Tu , Yunlei Liu , Shu Wu
IPC分类号： C07K16/30 , C12N5/0783 , C07K14/725 , C07K14/705 , C07K16/18 , C07K14/54 , A61K35/17 , A61K39/395 , A61K38/17 , A61K38/20 , A61K31/454 , A61P35/00 , A61P25/00 , A61P11/00
摘要： The present application provides GPC2-specific antibodies and antigen binding fragments thereof. A chimeric antigen receptor (CAR) that specifically binds glypican-2 (GPC2) comprising a GPC2-specific antibody, a transmembrane domain, and an intracellular signaling domain. T cells comprising the disclosed CAR constructs can be used for cancer immunotherapy.
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公开(公告)号：US11168146B2
公开(公告)日：2021-11-09
申请号：US16458872
申请日：2019-07-01
发明人： Fang Liang Zhang , Jianbing Zhang , Shu Wu
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are described.
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公开(公告)号：US20210275589A1
公开(公告)日：2021-09-09
申请号：US17258245
申请日：2019-07-12
IPC分类号： A61K35/17 , C07K16/28 , C12N5/0783
摘要： Immune cells (such as T cells) comprising a chimeric receptor (CR), a chimeric co-receptor (CCOR), and/or a co-receptor (COR) are provided.
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公开(公告)号：US20240041924A1
公开(公告)日：2024-02-08
申请号：US18026297
申请日：2021-09-29
发明人： Fengyuan TANG , Wang Zhang , Yuanyuan Peng , Zhongsheng HU , Shu Wu
CPC分类号： A61K35/17 , C12N5/0636 , C07K16/2833 , C07K16/242 , C07K16/2878 , C07K16/2851 , A61K39/4611 , A61K39/4631 , A61K39/464417 , A61P35/00 , A61K2239/13
摘要： A polypeptide comprising a chimeric antigen receptor (CAR) comprising (i) an extracellular domain capable of binding to a first antigen, (ii) a transmembrane domain, and (iii) an intracellular domain; and a domain capable of binding to a second antigen expressed on the surface of a cell that can interact with a T cell, wherein the CAR and the domain are fused by a peptide linker.
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公开(公告)号：US11673954B2
公开(公告)日：2023-06-13
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61P35/00 , A61K2039/505 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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