- 专利标题： Liposomes Containing Phosphorylated Tau Peptides for Inducing Sustained Immune Responses
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申请号： US18343349申请日： 2023-06-28
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公开(公告)号： US20230338535A1公开(公告)日： 2023-10-26
- 发明人: Andrea Pfeifer , Andreas Muhs , Wendy Galpern
- 申请人： Janssen Pharmaceuticals, Inc. , AC Immune SA
- 申请人地址： US NJ Titusville
- 专利权人： Janssen Pharmaceuticals, Inc.,AC Immune SA
- 当前专利权人： Janssen Pharmaceuticals, Inc.,AC Immune SA
- 当前专利权人地址： US NJ Titusville
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K9/127
摘要：
Methods for inducing a sustained immune response against phosphorylated Tau in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist, a helper T-cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain the sustained immune response.
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