Invention Publication
- Patent Title: MEMBRANE-BOUND IL-15, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF
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Application No.: US18309080Application Date: 2023-04-28
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Publication No.: US20230348548A1Publication Date: 2023-11-02
- Inventor: Justin GUNESCH , Mohammad HOSSAIN , Gagan BAJWA , Melinda MATA , Mamta KALRA
- Applicant: IMMATICS US, INC.
- Applicant Address: US TX Houston
- Assignee: IMMATICS US, INC.
- Current Assignee: IMMATICS US, INC.
- Current Assignee Address: US TX Houston
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; C12N15/86 ; C07K14/705 ; C07K16/00 ; C07K14/54 ; C07K14/725 ; A61K39/00 ; A61K39/39

Abstract:
The present disclosure relates to cells capable of co-expressing T cell receptors (“TCR”) together with membrane-bound IL-15 polypeptides and/or CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for modified IL-15, IL-15Rα, IL-15/IL-15Rα fusion polypeptide, and IL-15Rα/IL-15 fusion polypeptide sequences, vectors, and associated methods of making and using the same. The present disclosure further provides for modified CD8 sequences, vectors, and associated methods of making and using the same.
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