Radio frequency (RF) communication systems with coexistence management are provided herein. In certain embodiments, a method of coexistence management includes generating an RF observation signal based on observing a cellular transmit signal using a cellular front end system, processing the RF observation signal to generate digital observation data using a cellular transceiver, generating a digital wireless local area network (WLAN) receive signal based on processing an RF WLAN receive signal using a WLAN transceiver, compensating the digital baseband WLAN receive signal for RF signal leakage based on the digital observation data using a discrete time cancellation circuit of the WLAN transceiver.