发明公开
- 专利标题: Pharmaceutical Formulations
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申请号: US18152872申请日: 2023-01-11
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公开(公告)号: US20230355758A1公开(公告)日: 2023-11-09
- 发明人: Andrew Jeffrey Yates , James Gregory Clipstone
- 申请人: UCB BIOPHARMA SRL
- 申请人地址: BE Brussels
- 专利权人: UCB BIOPHARMA SRL
- 当前专利权人: UCB BIOPHARMA SRL
- 当前专利权人地址: BE Brussels
- 优先权: GB 04124.6 2016.03.10
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/22 ; A61K9/00 ; A61K47/18 ; A61K9/08 ; A61K47/20 ; A61K47/40
摘要:
The invention relates to a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. In addition, it relates to a method for reducing precipitation of an antibody or an antigen-bindmg fragment thereof in a liquid pharmaceutical formulation through addition of methionine and cyclodextrin. In particular, the liquid pharmaceutical formulations comprises an anti-sclerostin antibody, hydroxypropyl-gamma cyclodextrin and methionine and may be used in the treatment of a bone disorder associated with at least one of low bone formation, low bone mineral density, low bone mineral content, low bone mass, low bone quality and low bone strength, and especially for treating osteoporosis. Furthermore, the invention relates to a method of reducing inflammation at injection site in a mammalian subject comprising administering a therapeutically effective amount of a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclo dextrin and methionine.
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