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Patent Agency Ranking
公开(公告)号：US20240123065A1
公开(公告)日：2024-04-18
申请号：US18394323
申请日：2023-12-22
Applicant: UCB BIOPHARMA SRL
Inventor： Sandrine Durran , Andrew Jeffrey Yates
IPC: A61K39/395 , A61K47/12 , A61K47/18 , A61K47/26 , C07K16/24
CPC classification number: A61K39/39591 , A61K47/12 , A61K47/183 , A61K47/26 , C07K16/244 , C07K2317/76
Abstract: The present invention relates to pharmaceutical compositions comprising from an antibody or a fragment thereof which binds IL-17A and IL-17F and a combination of glycine, acetate buffer at pH 4.6 to 5.5 and polysorbate 80.
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公开(公告)号：US20230355758A1
公开(公告)日：2023-11-09
申请号：US18152872
申请日：2023-01-11
Applicant: UCB BIOPHARMA SRL
Inventor： Andrew Jeffrey Yates , James Gregory Clipstone
CPC classification number: A61K39/39591 , C07K16/22 , A61K9/0019 , A61K47/183 , A61K9/08 , A61K47/20 , A61K47/40 , C07K2317/24 , A61K2039/54
Abstract: The invention relates to a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. In addition, it relates to a method for reducing precipitation of an antibody or an antigen-bindmg fragment thereof in a liquid pharmaceutical formulation through addition of methionine and cyclodextrin. In particular, the liquid pharmaceutical formulations comprises an anti-sclerostin antibody, hydroxypropyl-gamma cyclodextrin and methionine and may be used in the treatment of a bone disorder associated with at least one of low bone formation, low bone mineral density, low bone mineral content, low bone mass, low bone quality and low bone strength, and especially for treating osteoporosis. Furthermore, the invention relates to a method of reducing inflammation at injection site in a mammalian subject comprising administering a therapeutically effective amount of a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclo dextrin and methionine.
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公开(公告)号：US11407835B2
公开(公告)日：2022-08-09
申请号：US16300522
申请日：2017-05-11
Applicant: UCB BIOPHARMA SRL
Inventor： Andrew Jeffrey Yates , Jan Ivo Massant
Abstract: The present invention relates to pharmaceutical compositions comprising an antibody or a fragment thereof suitable for freeze-drying (i.e. lyophilizing). The pharmaceutical compositions, which comprise an antibody or an antigen-binding fragment thereof; from 1% to 20% w/v sucrose; an amino acid or a mixture of amino acids; and surfactant, are provided as pharmaceutical compositions for freeze-drying; as freeze-dried (i.e. lyophilized) compositions which can be reconstituted into a solvent at the time of use or as reconstituted liquid formulations ready for administration.
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公开(公告)号：US12077796B2
公开(公告)日：2024-09-03
申请号：US16615419
申请日：2018-05-29
Applicant: UCB BIOPHARMA SRL
Inventor： Bassem Ben Yahia , Laetitia Malphettes , Nadine Kochanowski , Gill Renner , Sandrine Durran , Andrew Jeffrey Yates
CPC classification number: C12P21/02 , C07K1/16 , C07K16/00 , C12N5/0018 , C07K2317/14 , C07K2317/565 , C12N2500/32 , C12N2510/02 , C12N2511/00 , C12N2523/00
Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.
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公开(公告)号：US11857625B2
公开(公告)日：2024-01-02
申请号：US16765786
申请日：2018-11-13
Applicant: UCB BIOPHARMA SRL
Inventor： Sandrine Durran , Andrew Jeffrey Yates
IPC: A61K39/395 , A61K47/12 , A61K47/18 , A61K47/26 , C07K16/24
CPC classification number: A61K39/39591 , A61K47/12 , A61K47/183 , A61K47/26 , C07K16/244 , C07K2317/76
Abstract: The present invention relates to pharmaceutical compositions comprising from an antibody or a fragment thereof which binds IL-17A and IL-17F and a combination of glycine, acetate buffer at pH 4.6 to 5.5 and polysorbate 80.
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