- 专利标题: Dimeric Antigen Receptors (DAR) That Bind CD20
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申请号: US17820165申请日: 2022-08-16
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公开(公告)号: US20230061838A1公开(公告)日: 2023-03-02
- 发明人: Henry Hongjun Ji , Wenzhong Guo , Yanliang Zhang , Bei Bei Ding , Gunnar F. Kaufmann
- 申请人: Sorrento Therapeutics, Inc.
- 申请人地址: US CA San Diego
- 专利权人: Sorrento Therapeutics, Inc.
- 当前专利权人: Sorrento Therapeutics, Inc.
- 当前专利权人地址: US CA San Diego
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K14/725 ; C07K14/705 ; A61K35/17 ; A61P35/00 ; C12N5/0783 ; C12N15/62 ; C12N15/90
摘要:
The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a CD20 target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.
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