公开(公告)号：US20230061838A1

公开(公告)日：2023-03-02

申请号：US17820165

申请日：2022-08-16

申请人： Sorrento Therapeutics, Inc.

发明人： Henry Hongjun Ji ,  Wenzhong Guo ,  Yanliang Zhang ,  Bei Bei Ding ,  Gunnar F. Kaufmann

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0783 ,  C12N15/62 ,  C12N15/90

摘要： The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a CD20 target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.

公开(公告)号：US11027012B2

公开(公告)日：2021-06-08

申请号：US16111995

申请日：2018-08-24

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Randy Gastwirt ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00

摘要： There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-L1, PD-L1-binding fragments and derivatives of such antibodies, and PD-L1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-L1 related disorders or conditions, including various inflammatory disorders and various cancers.

公开(公告)号：US10925968B2

公开(公告)日：2021-02-23

申请号：US16455184

申请日：2019-06-27

申请人： Sorrento Therapeutics, Inc.

发明人： Yanwen Fu ,  Gunnar F. Kaufmann ,  Heehyoung Lee ,  Tong Zhu ,  Henry Hongjun Ji

IPC分类号： A61K47/58 ,  A61K47/59 ,  A61K31/365 ,  C07K16/18

摘要： Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.

公开(公告)号：US10799598B2

公开(公告)日：2020-10-13

申请号：US16052406

申请日：2018-08-01

申请人： Sorrento Therapeutics, Inc.

发明人： James T. Patterson ,  Gunnar F. Kaufmann ,  Yanwen Fu ,  Tong Zhu

IPC分类号： A61K47/68 ,  A61K47/55

摘要： Provided are bispecific conjugates having the general formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and their use in the treatment of cancer.

公开(公告)号：US10058609B2

公开(公告)日：2018-08-28

申请号：US15619389

申请日：2017-06-09

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Randy Gastwirt ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann

IPC分类号： A61K39/395 ,  C07K16/28

摘要： There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-L1, PD-L1-binding fragments and derivatives of such antibodies, and PD-L1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-L1 related disorders or conditions, including various inflammatory disorders and various cancers.

公开(公告)号：US20170182161A1

公开(公告)日：2017-06-29

申请号：US14864677

申请日：2015-09-24

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Randy Gastwirt ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann

IPC分类号： A61K39/395 ,  C07K16/28

摘要： There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-L1, PD-L1-binding fragments and derivatives of such antibodies, and PD-L1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-L1 related disorders or conditions, including various inflammatory disorders and various cancers.

公开(公告)号：US11318202B2

公开(公告)日：2022-05-03

申请号：US16374731

申请日：2019-04-03

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Gunnar F. Kaufmann

IPC分类号： A61K39/395 ,  C07K16/22 ,  C07K16/30

摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.

公开(公告)号：US10584168B2

公开(公告)日：2020-03-10

申请号：US15589051

申请日：2017-05-08

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann ,  Edwige Gros

IPC分类号： C07K16/28 ,  A61K39/395

摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.

公开(公告)号：US20190194300A1

公开(公告)日：2019-06-27

申请号：US16228570

申请日：2018-12-20

申请人： Sorrento Therapeutics, Inc.

发明人： Yanliang Zhang ,  Gunnar F. Kaufmann

IPC分类号： C07K16/12

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94

摘要： The present disclosure provides fully human variant anti-AIP2 variant antibodies, and antigen binding proteins thereof, having improved characteristics compared to the wild type anti-AIP2 antibody E7 from which the variant clones are derived. The variant anti-AIP2 antibodies exhibit improved binding to AIP1 and AIP4 as determined in an in vitro quorum sensing reporter assay, have improved thermal stability, provided complete protection against infection with two different strains of Staphylococcus aureus MRSA in pre-treated mice, and can be manufactured at higher yields.

公开(公告)号：US10272154B2

公开(公告)日：2019-04-30

申请号：US15330956

申请日：2015-04-14

申请人： Sorrento Therapeutics, Inc.

发明人： Heyue Zhou ,  Gunnar F. Kaufmann

IPC分类号： A61K39/395 ,  C07K16/30 ,  C07K16/22

摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.