![AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS](/docs/US/2023-03-09/US20230072265A1/abs.jpg.600x600.jpg)
- 专利标题： AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS
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申请号： US17789460申请日： 2020-12-24
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公开(公告)号： US20230072265A1公开(公告)日： 2023-03-09
- 发明人: Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkat Reddy GHOJALA , Venkataiah MALLAM
- 申请人： Thirumalai Rajan SRINIVASAN , MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 申请人地址： IN Telangana, Hyderabad; IN Sangareddy (Dist), Hyderabad, Telangan
- 专利权人： Thirumalai Rajan SRINIVASAN,MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 当前专利权人： Thirumalai Rajan SRINIVASAN,MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 当前专利权人地址： IN Telangana, Hyderabad; IN Sangareddy (Dist), Hyderabad, Telangan
- 优先权： IN201941054251 20191227
- 国际申请： PCT/IN2020/051049 WO 20201224
- 主分类号： C07D239/54
- IPC分类号： C07D239/54
![AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS](/abs-image/US/2023/03/09/US20230072265A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts. The compound of formula (I) is represented by the following structural formula:
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