专利检索 ap:("Thirumalai Rajan SRINIVASAN" OR "MSN LABORATORIES PRIVATE LIMITED, R&D CENTER") AND inv:"Venkat Reddy GHOJALA" 第 1 页

1.

发明申请
AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS 有权

公开(公告)号：US20230072265A1

公开(公告)日：2023-03-09

申请号：US17789460

申请日：2020-12-24

申请人： Thirumalai Rajan SRINIVASAN , MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkat Reddy GHOJALA , Venkataiah MALLAM

IPC分类号： C07D239/54

摘要： The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts. The compound of formula (I) is represented by the following structural formula:

2.

发明申请
IMPROVED PROCESS FOR THE PREPARATION OF 2-(3,5-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHS THEREOF 有权

公开(公告)号：US20220251052A1

公开(公告)日：2022-08-11

申请号：US17624591

申请日：2020-07-04

申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkat Reddy GHOJALA , Rajeshwar Reddy SAGYAM , Markandeya BEKKAM

IPC分类号： C07D263/57 , C07C213/08

摘要： The present invention relates to process for the preparation of 2-(3,5-dichlorophenyl)-1,3- benzoxazole-6-carboxylic acid of formula (I), its pharmaceutically acceptable salts and polymorphs thereof which are used in the treatment of cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis.

3.

发明申请
SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF 审中-公开

公开(公告)号：US20200283413A1

公开(公告)日：2020-09-10

申请号：US16645472

申请日：2018-09-07

申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkat Reddy GHOJALA , Rajeshwar Reddy SAGYAM , Srinivasulu RANGINENI , Rajashekar KOMMERA , Markandeya BEKKAM

IPC分类号： C07D403/06

摘要： The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2′-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.