Methods for automatic calibration of a braille interface. In embodiments, a user begins typing braille characters in 2×3 matrix into an interface without an initial calibration step. The implementing system detects the patterns of the keystrokes and determines the orientation and placement of the user's hands by comparing the keystrokes against known braille characters, identifying which row and column of the 2×3 matrix within which each finger is positioned. The interface is then calibrated based on the identified positions of the fingers within the 2×3 matrix. For touch interfaces, the surface area of each finger may also be used to enhance identification of fingers. Other embodiments may be described and/or claimed.