![Sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetate and pharmaceutical compositions thereof](/docs/US/2023-03-30/US20230095980A1/abs.jpg.600x600.jpg)
- 专利标题： Sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetate and pharmaceutical compositions thereof
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申请号： US17802651申请日： 2021-03-01
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公开(公告)号： US20230095980A1公开(公告)日： 2023-03-30
- 发明人: Helmut BUSCHMANN , Thomas GOLDNER , Jessica REDMER , Andrea HAWE , Matthias LUCKE , Dorothea HOHMANN , Monica ROSA
- 申请人： AIC246 AG & Co. KG
- 申请人地址： DE Wuppertal
- 专利权人： AIC246 AG & Co. KG
- 当前专利权人： AIC246 AG & Co. KG
- 当前专利权人地址： DE Wuppertal
- 优先权： EP20159699.6 20200227
- 国际申请： PCT/EP2021/055062 WO 20210301
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K9/19
![Sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetate and pharmaceutical compositions thereof](/abs-image/US/2023/03/30/US20230095980A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to new stable pharmaceutical compositions containing sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextrin, lysin, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.
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