公开(公告)号：US20230138444A1

公开(公告)日：2023-05-04

申请号：US17802558

申请日：2021-03-01

申请人： AIC246 AG & Co. KG

发明人： Helmut BUSCHMANN ,  Thomas GOLDNER ,  Jessica REDMER ,  Jordi Carles CERON BERTRAN ,  Andrea HAWE ,  Matthias LUCKE ,  Dorothea HOHMANN ,  Monica ROSA

IPC分类号： A61K31/517 ,  A61K47/10 ,  A61K47/26 ,  A61K47/18 ,  A61K47/32 ,  A61K9/19

摘要： The present invention relates to new stable pharmaceutical compositions containing 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid and sodium ions that are essentially free from complexing solubilizing agents, such as PEG, cyclodextrin, lysine, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.

公开(公告)号：US20230095980A1

公开(公告)日：2023-03-30

申请号：US17802651

申请日：2021-03-01

申请人： AIC246 AG & Co. KG

发明人： Helmut BUSCHMANN ,  Thomas GOLDNER ,  Jessica REDMER ,  Andrea HAWE ,  Matthias LUCKE ,  Dorothea HOHMANN ,  Monica ROSA

IPC分类号： A61K31/517 ,  A61K9/19

摘要： The present invention relates to new stable pharmaceutical compositions containing sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextrin, lysin, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.