发明申请
- 专利标题： SMYD Inhibitors
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申请号： US17532422申请日： 2021-11-22
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公开(公告)号： US20230101819A1公开(公告)日： 2023-03-30
- 发明人: Megan Alene Cloonan FOLEY , Kevin Wayne KUNTZ , James Edward John MILLS , Lorna Helen MITCHELL , Michael John MUNCHHOF , Darren Martin HARVEY
- 申请人： EPIZYME, INC.
- 申请人地址： US MA Cambridge
- 专利权人： EPIZYME, INC.
- 当前专利权人： EPIZYME, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07D451/04
- IPC分类号： C07D451/04 ; C07D213/81 ; C07D213/82 ; C07D231/14 ; C07D233/90 ; C07D401/12 ; C07D241/26 ; C07D249/04 ; C07D261/10 ; C07D263/34 ; C07D275/03 ; C07D209/08 ; C07D277/56 ; C07C271/18 ; C07D205/04 ; C07D211/34 ; C07D237/24 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D413/12 ; C07D417/14
摘要：
The present disclosure provides carboxamides and sulfonamides having Formula (I); and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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