Invention Application
- Patent Title: SYSTEMS, METHODS, AND COMPOSITIONS TO IDENTIFY NEW PROTEIN TARGETS OF A CHEMICAL COMPOUND OR ITS DERIVATIVES
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Application No.: US18067308Application Date: 2022-12-16
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Publication No.: US20230118154A1Publication Date: 2023-04-20
- Inventor: GEEN-DONG CHANG , MING-SHYUE LEE , CHENG-HAN YU
- Applicant: GEEN-DONG CHANG , MING-SHYUE LEE , CHENG-HAN YU
- Applicant Address: TW Taipei City; TW Taipei City; TW Taipei City
- Assignee: GEEN-DONG CHANG,MING-SHYUE LEE,CHENG-HAN YU
- Current Assignee: GEEN-DONG CHANG,MING-SHYUE LEE,CHENG-HAN YU
- Current Assignee Address: TW Taipei City; TW Taipei City; TW Taipei City
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/543

Abstract:
Systems and methods to identify new protein targets of a chemical compound or its derivatives were described. The methods can be used for detection of new binding partners as long as the chemical compound can covalently bind to the protein targets. Once protein targets are resolved, information related to new protein targets can then be used to couple with real-world patient data such as adverse events, efficacy data, and disease correlation data to deduce real-world evidence. Systems collectively with all this information can aide clinical development and use of pharmaceutical drug. Methods are provided for detection of covalently bound phenyl vinyl sulfone (PVS) or its derivatives, and afatinib or its derivatives. Furthermore, generation of antiserum recognizing carrier bound PVS or carrier bound afatinib is described. PRMT1 is described as a new target of PVS and RRM1, RRM2, and NFKB are described as new targets of afatinib.
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