公开(公告)号：US20230118154A1

公开(公告)日：2023-04-20

申请号：US18067308

申请日：2022-12-16

Applicant: GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

Inventor： GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

IPC: G01N33/68 ,  G01N33/543

Abstract: Systems and methods to identify new protein targets of a chemical compound or its derivatives were described. The methods can be used for detection of new binding partners as long as the chemical compound can covalently bind to the protein targets. Once protein targets are resolved, information related to new protein targets can then be used to couple with real-world patient data such as adverse events, efficacy data, and disease correlation data to deduce real-world evidence. Systems collectively with all this information can aide clinical development and use of pharmaceutical drug. Methods are provided for detection of covalently bound phenyl vinyl sulfone (PVS) or its derivatives, and afatinib or its derivatives. Furthermore, generation of antiserum recognizing carrier bound PVS or carrier bound afatinib is described. PRMT1 is described as a new target of PVS and RRM1, RRM2, and NFKB are described as new targets of afatinib.

公开(公告)号：US20200333332A1

公开(公告)日：2020-10-22

申请号：US16847206

申请日：2020-04-13

Applicant: GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

Inventor： GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

IPC: G01N33/544 ,  G01N33/563 ,  G16B35/20 ,  A61K47/62 ,  A61K38/44 ,  A61K38/17 ,  A61K38/45

Abstract: Systems and methods to identify new protein targets of a chemical compound or its derivatives were described. The methods can be used for detection of new binding partners as long as the chemical compound can covalently bind to the protein targets. Once protein targets are resolved, information related to new protein targets can then be used to couple with real-world patient data such as adverse events, efficacy data, and disease correlation data to deduce real-world evidence. Systems collectively with all this information can aide clinical development and use of pharmaceutical drug. Methods are provided for detection of covalently bound phenyl vinyl sulfone (PVS) or its derivatives, and afatinib or its derivatives. Furthermore, generation of antiserum recognizing carrier bound PVS or carrier bound afatinib is described. PRMT1 is described as a new target of PVS and RRM1, RRM2, and NFKB are described as new targets of afatinib.