An electronic device with a detachable plug includes a main body and a plug body. The main body has a fitting recess, a first conductive terminal group, and a press portion. The first conductive terminal group is disposed in the fitting recess. The press portion is located on at least one side of the fitting recess, and the press portion is formed by at least one exterior side plate and at least one interior side plate of the main body together. A press space exists between the at least one exterior side plate and the at least one interior side plate. The at least one interior side plate has an opening communicating with the fitting recess, and the at least one exterior side plate has a bump passing through the opening. The plug body is detachably configured in the fitting recess of the main body.