- 专利标题: IMMUNIZATION OF LARGE MAMMALS WITH LOW DOSES OF RNA
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申请号: US18080150申请日: 2022-12-13
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公开(公告)号: US20230136704A1公开(公告)日: 2023-05-04
- 发明人: Andrew GEALL
- 申请人: GLAXOSMITHKLINE BIOLOGICALS SA
- 申请人地址: BE Rixensart
- 专利权人: GLAXOSMITHKLINE BIOLOGICALS SA
- 当前专利权人: GLAXOSMITHKLINE BIOLOGICALS SA
- 当前专利权人地址: BE Rixensart
- 主分类号: C12N15/117
- IPC分类号: C12N15/117 ; C12N15/86 ; A61K39/155 ; A61K39/39 ; A61K39/12 ; A61P31/12 ; A61P37/04 ; A61K48/00
摘要:
RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus, the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.
公开/授权文献
- US2640386A Shell loading device 公开/授权日:1953-06-02