In a mobility including a negative pressure space and method for controlling a pressure of the mobility in which the mobility is used a general vehicle in normal times, and when a special situation such as transferring infectious disease patients occurs, an internal space includes a general space and a negative pressure space by a partition wall, so that the infectious disease patients are safely transferred through the negative pressure space and the spread of infectious diseases is prevented. As a result, the usability of a vehicle is increased, and it is possible to respond to such special situation.