- 专利标题： LACTAM AND LACTONE DERIVATIVES FOR USE IN THE TREATMENT OF A VIRAL INFECTION SUCH AS COVID-19
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申请号： US18253664申请日： 2021-11-19
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公开(公告)号： US20240000794A1公开(公告)日： 2024-01-04
- 发明人: Patrice SOUMILLION , Pierre GALKA
- 申请人： UNIVERSITÉ CATHOLIQUE DE LOUVAIN
- 申请人地址： BE Louvain-la-Neuve
- 专利权人： UNIVERSITÉ CATHOLIQUE DE LOUVAIN
- 当前专利权人： UNIVERSITÉ CATHOLIQUE DE LOUVAIN
- 当前专利权人地址： BE Louvain-la-Neuve
- 优先权： EP 208998.3 2020.11.20
- 国际申请： PCT/EP2021/082351 2021.11.19
- 进入国家日期： 2023-05-19
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61P31/14
摘要：
Lactam or lactone derivatives of formula Ia:
or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is NH or O; X2 is —OH, —O-alkyl, —NH2, an amino acid group or a peptide group, wherein the amino acid group or peptide group is linked to the carbonyl group by its N-terminal residue; Z1 is S, SO, SO2, O, CR3 or NR4; and R1, R2, R3 and R4 each independently are H, alkyl or aryl. Also, the use of lactam or lactone derivatives of formula Ia in treating a disease caused by a viral infection, especially a coronavirus infection and/or a viral respiratory infection, such as COVID-19 caused by SARS-CoV-2.
or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is NH or O; X2 is —OH, —O-alkyl, —NH2, an amino acid group or a peptide group, wherein the amino acid group or peptide group is linked to the carbonyl group by its N-terminal residue; Z1 is S, SO, SO2, O, CR3 or NR4; and R1, R2, R3 and R4 each independently are H, alkyl or aryl. Also, the use of lactam or lactone derivatives of formula Ia in treating a disease caused by a viral infection, especially a coronavirus infection and/or a viral respiratory infection, such as COVID-19 caused by SARS-CoV-2.
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