公开(公告)号：US20240000794A1

公开(公告)日：2024-01-04

申请号：US18253664

申请日：2021-11-19

申请人： UNIVERSITÉ CATHOLIQUE DE LOUVAIN

发明人： Patrice SOUMILLION ,  Pierre GALKA

IPC分类号： A61K31/54 ,  A61P31/14

CPC分类号： A61K31/54 ,  A61P31/14

摘要： Lactam or lactone derivatives of formula Ia:




or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is NH or O; X2 is —OH, —O-alkyl, —NH2, an amino acid group or a peptide group, wherein the amino acid group or peptide group is linked to the carbonyl group by its N-terminal residue; Z1 is S, SO, SO2, O, CR3 or NR4; and R1, R2, R3 and R4 each independently are H, alkyl or aryl. Also, the use of lactam or lactone derivatives of formula Ia in treating a disease caused by a viral infection, especially a coronavirus infection and/or a viral respiratory infection, such as COVID-19 caused by SARS-CoV-2.