A method for transmitting a discrete fourier transform (DFT) DFT-S-OFDM signal including frequency domain reference symbols is disclosed. The method comprises: determining to null a plurality of data symbols prior to DFT-spreading; performing DFT-spreading including the determined null data symbols; puncturing an interleaved output of the DFT-spreading; inserting reference symbols in a frequency domain of the punctured and interleaved DFT-S-OFDM signal; and transmitting the DFT-S-OFDM signal with inserted reference symbols to a receiver. The transmitted DFT-S-OFDM signal enables the receiver to apply zeros corresponding to the reference symbols to an interleaved input of DFT-despreading, and cancel interference due to the puncturing by using all outputs of the DFT-despreading.