- 专利标题: MODULATING BHLHE40 IN THE DIFFERENTIATION OF TYPE 1 REGULATORY T CELLS AND CONTROLLING T CELL EXHAUSTION
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申请号: US18036111申请日: 2021-11-12
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公开(公告)号: US20240018474A1公开(公告)日: 2024-01-18
- 发明人: Maria Grazia Roncarolo , Molly Kathryn Javier Uyeda , Robert Freeborn
- 申请人: The Board of Trustees of the Leland Stanford Junior University
- 申请人地址: US CA Stanford
- 专利权人: The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人: The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址: US CA Stanford
- 国际申请: PCT/US2021/059137 2021.11.12
- 进入国家日期: 2023-05-09
- 主分类号: C12N5/0783
- IPC分类号: C12N5/0783 ; A61K35/17
摘要:
Methods and cell compositions are provided in which expression of BHLHE40 is modulated to direct T cell phenotype and function.
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