Invention Publication
- Patent Title: PROTEINS COMPRISING DELTA-LIKE LIGAND 3 (DLL3) ANTIGEN BINDING DOMAINS AND THEIR USES
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Application No.: US18249807Application Date: 2021-10-21
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Publication No.: US20240025992A1Publication Date: 2024-01-25
- Inventor: Danlin YANG , Sanjaya SINGH , Scott R. BRODEUR , Jill M. CARTON , Rajkumar GANESAN , Jennifer HERTZOG , Theresa MCDEVITT , Kristen M. PICHA , Ryan M. SMITH , Adam ZWOLAK , Sathyadevi VENKATARAMANI , Gordon D. POWERS
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- International Application: PCT/IB2021/059724 2021.10.21
- Date entered country: 2023-04-20
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K47/68 ; A61P35/00 ; A61K49/00
Abstract:
Antibodies and antigen binding regions that bind delta-like protein 3 (DLL3) are described. Multispecific antigen-binding constructs, such as bispecific antibodies, containing the antigen-binding regions that bind to DLL3 are also described. The application also describes methods of treatment or detection using the anti-DLL3 antibodies, antigen-binding fragments or multispecific antigen-binding constructs thereof, and related molecules, compositions and methods.
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