公开(公告)号：US20240025992A1

公开(公告)日：2024-01-25

申请号：US18249807

申请日：2021-10-21

Applicant: Janssen Biotech, Inc.

Inventor： Danlin YANG ,  Sanjaya SINGH ,  Scott R. BRODEUR ,  Jill M. CARTON ,  Rajkumar GANESAN ,  Jennifer HERTZOG ,  Theresa MCDEVITT ,  Kristen M. PICHA ,  Ryan M. SMITH ,  Adam ZWOLAK ,  Sathyadevi VENKATARAMANI ,  Gordon D. POWERS

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K49/00

CPC classification number: C07K16/28 ,  A61K47/6849 ,  C07K16/2809 ,  C07K2319/30 ,  A61K49/0002 ,  C07K2317/622 ,  C07K2317/31 ,  A61P35/00

Abstract: Antibodies and antigen binding regions that bind delta-like protein 3 (DLL3) are described. Multispecific antigen-binding constructs, such as bispecific antibodies, containing the antigen-binding regions that bind to DLL3 are also described. The application also describes methods of treatment or detection using the anti-DLL3 antibodies, antigen-binding fragments or multispecific antigen-binding constructs thereof, and related molecules, compositions and methods.