In variants, the method for determining dispensing volume for a liquid handler 110 can include: dispensing a droplet using the liquid hander 110, sampling a set of measurements of the droplet, determining the droplet volume based on the set of measurements, and/or any other suitable steps. In variants, the system 100 can include: the liquid handler 110, a droplet vessel 130, a measurement system 150, and/or any other suitable components.