- 专利标题: T CELL AND ANTIGEN-PRESENTING CELL ENGAGERS AND USES THEREOF
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申请号: US18026297申请日: 2021-09-29
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公开(公告)号: US20240041924A1公开(公告)日: 2024-02-08
- 发明人: Fengyuan TANG , Wang Zhang , Yuanyuan Peng , Zhongsheng HU , Shu Wu
- 申请人: Nanjing Legend Biotech Co., Ltd.
- 申请人地址: CN Nanjing
- 专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人地址: CN Nanjing
- 优先权: WO TCN2020118988 2020.09.29
- 国际申请: PCT/CN2021/121535 2021.09.29
- 进入国家日期: 2023-03-14
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; C12N5/0783 ; C07K16/28 ; C07K16/24 ; A61K39/00 ; A61P35/00
摘要:
A polypeptide comprising a chimeric antigen receptor (CAR) comprising (i) an extracellular domain capable of binding to a first antigen, (ii) a transmembrane domain, and (iii) an intracellular domain; and a domain capable of binding to a second antigen expressed on the surface of a cell that can interact with a T cell, wherein the CAR and the domain are fused by a peptide linker.
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