Invention Publication
- Patent Title: A DFL-PRODUCING STRAIN
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Application No.: US18258770Application Date: 2021-12-21
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Publication No.: US20240043891A1Publication Date: 2024-02-08
- Inventor: Margit PEDERSEN
- Applicant: GLYCOM A/S
- Applicant Address: DK Hørsholm
- Assignee: GLYCOM A/S
- Current Assignee: GLYCOM A/S
- Current Assignee Address: DK Hørsholm
- Priority: DK 202001450 2020.12.22
- International Application: PCT/EP2021/086932 2021.12.21
- Date entered country: 2023-06-21
- Main IPC: C12P19/18
- IPC: C12P19/18 ; C12N9/10
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Abstract:
The present invention relates to a genetically modified cell expressing an α-1,2-fucosyltransferase and an α-1,3-fucosyltransferase, and a transporter protein of the major facilitator superfamily (MFS) and to a method for recombinant production of human milk oligosaccharides (HMOs) using said genetically modified cell. More particularly, the invention provides a method for recombinant production of and a genetically modified cell capable of producing difucosyllactose (DFL) as the most abundant HMO, with a relatively low content of 3-fucosyllactose (3FL) and/or 2′-fucosyllactose (2′FL).
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