• 专利标题: A DFL-PRODUCING STRAIN
  • 申请号: US18258770
    申请日: 2021-12-21
  • 公开(公告)号: US20240043891A1
    公开(公告)日: 2024-02-08
  • 发明人: Margit PEDERSEN
  • 申请人: GLYCOM A/S
  • 申请人地址: DK Hørsholm
  • 专利权人: GLYCOM A/S
  • 当前专利权人: GLYCOM A/S
  • 当前专利权人地址: DK Hørsholm
  • 优先权: DK 202001450 2020.12.22
  • 国际申请: PCT/EP2021/086932 2021.12.21
  • 进入国家日期: 2023-06-21
  • 主分类号: C12P19/18
  • IPC分类号: C12P19/18 C12N9/10
A DFL-PRODUCING STRAIN
摘要:
The present invention relates to a genetically modified cell expressing an α-1,2-fucosyltransferase and an α-1,3-fucosyltransferase, and a transporter protein of the major facilitator superfamily (MFS) and to a method for recombinant production of human milk oligosaccharides (HMOs) using said genetically modified cell. More particularly, the invention provides a method for recombinant production of and a genetically modified cell capable of producing difucosyllactose (DFL) as the most abundant HMO, with a relatively low content of 3-fucosyllactose (3FL) and/or 2′-fucosyllactose (2′FL).
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