Systems and methods of electrostatically spraying a treatment solution are disclosed that include electrostatically charging, by a cartridge assembled with a handheld portable electrostatic device, a treatment solution. The handheld portable electrostatic device can include a housing, the cartridge removably disposed in the housing. The cartridge can include a cartridge housing, at least one electrode to electrostatically charge and ionize molecules of the treatment solution of the cartridge, and a nozzle positioned at a distal end of the cartridge housing, the nozzle of the cartridge being configured to deliver the electrostatically charged treatment solution and configured to be in fluid communication with an air supply tube in fluid communication with a pump in the housing.