Image acquisition and analysis systems for efficiently generating high resolution geo-referenced spectral imagery of a region of interest. In some examples, aerial spectral imaging systems for remote sensing of a geographic region, such as a vegetative landscape are disclosed for monitoring the development and health of the vegetative landscape. In some examples photogrammetry processes are applied to a first set of image frames captured with a first image sensor having a first field of view to generate external orientation data and surface elevation data and the generated external orientation data is translated into external orientation data for other image sensors co-located on the same apparatus for generating geo-referenced images of images captured by the one or more other image sensors.