A system in a transport refrigeration unit (TRU) for driving a compressor and/or fan(s) of the TRU by a variable frequency drive (VFD) that is operable using AC power comprises the VFD operatively connected between the compressor and one or more ac power source such as an engine-generator assembly of the TRU and/or an electrical grid. The same VFD or a different VFD is also operatively connected between the AC power source and fan(s) associated with an evaporator, and a condenser of the TRU. The VFD is configured to be operated by the AC power sources. The VFD is operable to receive a 3-phase AC power ranging from 200 to 650 volts and 0.25 to 25 KW from at least one of the AC power source, convert the received 3-phase AC power to supply AC or DC power to a motor associated with the compressor and/or the fan(s).