Systems and methods relate to processing digital pathology images. More specifically, techniques include accessing a digital pathology image that depicts a section of a biological sample, wherein the digital pathology image comprises regions displaying reactivity to a plurality of stains. For each of a plurality of tiles of the digital pathology image, a local-density measurement is calculated for each of a plurality of biological object types. One or more spatial-distribution metrics may be generated for the biological object types based at least in part on the calculated local-density measurements. A tumor immunophenotype may then be generated for the digital pathology image based at least in part on the local-density measurements or the one or more spatial-distribution metrics.