Systems and methods for providing multiple lumens within a single sample probe of an autosampler system are described. In an aspect, a sample probe for an autosampler system includes, but is not limited to, a tube enclosing at least a portion of a plurality of lumens; and a controller communicatively coupled with a fluid handling system to introduce or draw one or more fluids through each of the plurality of lumens, wherein during a droplet purge operation, the controller is configured to expel a gas from a tip of one of the lumens to purge a droplet of fluid from the tip.